角膜共聚焦显微镜在干眼随访诊治中的应用

Application of confocal microscopy corneal examination in the follow-up treatments of dry eye disease

目的:评价角膜共聚焦显微镜检查在干眼随访诊治中的作用。方法:选取干眼新发病例150例(300眼),随机分为A、B两组,随访治疗半年。A组患者根据随访角膜共聚焦显微镜检查结果调整治疗方案,B组根据常规干眼检查结果调整治疗方案,两组所用具体治疗药物及方法相同。结果:A组患者总的好转率为63%,明显高于B组的35%;并且经治疗后,A组患者的平均泪液分泌量(SⅠt)及泪膜破裂时间(BUT)明显好于B组。结论:根据角膜共聚焦显微镜检查结果调整干眼治疗方案效果明显好于传统随访治疗方案。

Objective： To evaluate the role of confocal microscopy corneal examination in determining the treatments during the follow-up period of dry eye patients.Methods： 150 dry eye patients （ 300 eyes ） were diagnosed and treated, and grouped A and B, followed up for half a year.The treatments of patients in group A were modified according to the changes of confocal microscopy corneal examination, whereas those of group B were done based on the usual dry eye clinical tests, except for which, the drugs and treatments were consistent between group A and B.Results： The total improvement rate of patients in group A were 63%, which was significantly higher than that of group B （ 35%）; the SIt and BUT levels of patients in group A after treatments were both significantly better than those of group B.Conclusion： The therapeutic effect of dry eye patients modified aaccording to the changes of confocal microscopy corneal examination is significantly better than that modified according to the usual follow-up dry eye tests.