EOF方案术前动脉介入化疗对胃癌患者血糖影响的回顾性研究

Retrospective study on glucose metabolism disorders induced by preoperative intra-arterial infusion chemotherapy with EOF regimen in patients with gastric cancer

目的:探讨胃癌患者接受EOF方案术前动脉介入化疗前后血糖水平的变化,并分析相关因素对血糖变化的影响。方法:收集2012年至2014年间92例接受EOF方案术前动脉介入化疗的胃癌患者在介入化疗前及介入化疗后24 h的空腹血糖检验结果及相关临床资料,进行回顾性分析。结果:EOF方案动脉介入化疗后患者血糖平均水平增加,与介入化疗前相比差异有统计学意义(P<0.01)。患者年龄、性别、肿瘤部位、肿瘤分期等相关因素对血糖升高的影响差异无统计学意义(P>0.05)。合并糖尿病的胃癌患者动脉介入化疗后血糖升高水平明显高于非糖尿病患者,差异有统计学意义(P<0.001)。结论:EOF方案动脉介入化疗可使胃癌患者的血糖升高,尤其是合并糖尿病的胃癌患者血糖升高尤为明显,在积极治疗原发病的同时应注意监测患者血糖并及时处理。

Objective：To explore the effects of the preoperative intra-arterial infusion chemotherapy（ PAIC） with EOF regimen on blood glucose of gastric cancer patients and to find the influencing factors.Methods：92 patients with gastric cancer participated in the study; they had received PAIC from 2012 to 2014 in our hospital.The regimen consisted of EPI 50 mg · m-2 , OXA 130 mg · m-2 , and 5-FU 750 mg· m-2 .Their blood glucose was detected on schedule before and after chemotherapy; clinical factors were collected.Some changed regularity on blood glucose and the influential factors were found after chemotherapy.Results： After PAIC, patients＆#39;blood glucose was higher than before the treatment （ P〈0.01 ） .Age, gender, tumor location and tumor stage had no obvious impact on blood glucose changes before and after PAIC （ P〉0.05 ） .Gastric cancer patients with diabetes were more vulnerable to induce blood glucose rose after PAIC（ P〈0.001） .Conclusion：PAIC could enhance blood glucose level in gastric cancer patients, especially in patients with diabetes mellitus.In order to complete tumor chemotherapy safely and successfully, strict monitoring of blood glucose and appropriate measures to control high blood sugar should be taken.