复方苦参注射液联合盐酸羟考酮治疗肺癌疼痛疗效观察

Observation on Efficacy of Compound Sophorae Flavescentis Radix Injection Combined with Oxycodone Hydrochloride in Treating Lung Cancer Pain

目的观察复方苦参注射液联合盐酸羟考酮治疗肺癌疼痛的近期疗效。方法将60例中晚期肺癌疼痛患者随机分为治疗组和对照组各30例。对照组给予最佳对症支持治疗联合盐酸羟考酮,治疗组在对照组基础上给予复方苦参注射液20 m L加入0.9%氯化钠注射液250 m L中静脉滴注,每日1次,连用14 d。观察2组患者治疗前后卡氏评分、疼痛程度及不良反应。结果治疗组治疗后疼痛得到明显缓解(P<0.01),对照组疼痛程度治疗前后比较差异无统计学意义(P>0.05),治疗后组间比较差异无统计学意义(P>0.05)。治疗组治疗后卡氏评分明显高于治疗前及对照组,差异均有统计学意义(P<0.05);对照组治疗前后卡氏评分差异无统计学意义(P>0.05)。结论复方苦参注射液联合盐酸羟考酮能明显缓解中晚期肺癌患者疼痛,提高生活质量,且无明显不良反应。

Objective To observe the near-term efficacy of Compound Sophorae Flavescentis Radix Injection combined with oxycodone hydrochloride in treating lung cancer pain. Methods Sixty patients with advanced lung cancer were randomly divided into treatment group(30 cases) and control group(30 cases). The control group was treated by the best symptomatic and supportive treatment combined with oxycodone hydrochloride, while the treatment group was treated by Compound Sophorae Flavescentis Radix Injection 20 m L which was added into 250 m L normal saline solution for intravenous drip additionally, once a day for 14 days. KPS score before and after treatment, analgesic effect, and adverse action of the two groups were observed. Results After treatment, the pain in patients of treatment group was significantly improved(P <0.01), but it was not statistically different compared with the control group(P >0.05). KPS in patients of treatment group was significantly improved compared with that of before treatment and the comrol group, with statistical significance(P >0.05). There was no statistical significance in KPS score between before and after treatment of the control group(P > 0.05). Conclusion Compound Sophorae Flavescentis Radix Injection combine with oxycodone hydrochloride can significantly relieve patients' pain and improve their life quality, with no obvious adverse reactions.