青蒿素类抗疟制剂研究概述

Research Progress of Artemisinins-based Antimalarial Agents

青蒿素是我国于20世纪70年代发现的抗疟活性成分。为满足不同的用药需要,研究人员近年来对其化学结构进行了改造,获得了系列青蒿素类衍生物,并根据药物的理化性质和实际临床需求,研制出了多种青蒿素类抗疟制剂,其中常用的制剂有片剂、栓剂和注射剂等。随着制剂技术不断发展,技术人员针对青蒿素类的纳米注射剂、经皮制剂和黏膜给药制剂等新剂型进行了大量研究。本文根据不同的给药途径,对近年来青蒿素类抗疟制剂的研究情况进行系统的整理和论述。

Artemisinin is the antimalarial active ingredient, which is discovered by Chinese scientists in 1970 s. The chemical structure of artemisinin is modified or altered to obtain a series of analogues to satisfy the medication requirements. According to the physicochemical properties of medicines and actual clinical necessities, the preparations of artemisinins are developed and the common preparations include tablet, suppository, injection, etc.. With the developing of technology, researchers have conducted a large number of studies on the artemisinins nanoparticles injection, transdermal drug delivery systems, mucosal drug delivery systems and etc. This article systematically collected and discussed the recent studies on the antimalarial preparations of artemisinins in line with different administration routes.