湿生扁蕾-苦豆子不同比例配伍抗炎、镇痛作用研究

Analgesic and Anti-inflammatory Effects of Different Compatibility of Gentianopsis Paludosa and Sophora Alopecuroide on Mice

目的比较湿生扁蕾与苦豆子不同比例配伍对小鼠的镇痛、抗炎作用。方法将小鼠随机分为正常组、阳性药组、不同配伍组,每组10只,连续灌胃7 d,每日1次。采用冰醋酸扭体法和热板致痛法比较不同配伍的镇痛作用,采用二甲苯致小鼠耳肿胀法和琼脂致肉芽肿法比较不同配伍的抗炎作用。结果与正常组比较,湿生扁蕾复方镇痛、抗炎作用明显(P<0.01),湿生扁蕾和苦豆子按20∶0.6和20∶0.9配伍时,镇痛、抗炎效果较好。结论湿生扁蕾-苦豆子配伍具有较好的镇痛、抗炎作用,以湿生扁蕾和苦豆子20∶0.6配伍最佳。

Objective To compare analgesic and anti-inflammatory effects of Gentianopsis Paludosa and Sophora Alopecuroide of different kinds of compatibility on the mice. Methods Mice were randomly divided into normal control group, positive medicine group, and different kinds of compatibility groups, 10 mice in each group. Mice received gavage for successive 7 days, once a day. Glacial acetic acid twist body method and hot board to pain method were used to observe and compare analgesic effects of different kinds of compatibility. Xylene to ear swelling method and agar to granulation swollen method were used to observe and compare inflammatory effects of different kinds of compatibility. Results Compared with normal group, compound Gentianopsis Paludosa had obvious analgesic and anti-inflammatory effects(P < 0.01). When the ratio of Gentianopsis Paludosa and Sophora Alopecuroide was 20∶0.6 and 20∶0.9, the analgesic and anti-inflammatory effects were the best. Conclusion Gentianopsis Paludosa and Sophora Alopecuroide have good analgesic and anti-inflammatory effects, among which, when the ratio of Gentianopsis Paludosa and Sophora Alopecuroide is 20∶0.6, the best effects show.