红花黄色素联合贝那普利对早期糖尿病肾病患者肾功能的影响

Effect of Soffor Yellow Combined with Benazepril on the Renal Function of Patients with Early Diabetic Nephropathy

目的:探讨红花黄色素联合贝那普利对早期糖尿病肾病患者肾功能的影响。方法:选择2014年1月至2014年8月我院收治的120例早期糖尿病肾病患者为研究对象,并根据随机数字法,将其分为对照组(贝那普利治疗)和观察组(红花黄色素联合贝那普利治疗),每组各60例患者,观察和比较治疗前后两组患者中医证候变化情况、临床疗效以及血清胱抑素C(Cys C)、同型半胱氨酸(Hcy)、血肌酐(Scr)、尿素氮(BUN)、空腹血糖(FBG)、餐后2h血糖(2h PG)、糖化血红蛋白(Hb A1C)水平的变化情况。结果:与治疗前相比,两组治疗后的中医症候总积分、FBG、2h PG、Hb A1C、Cys C、Hcy、Scr、BUN水平均明显降低(P<0.05);且观察组治疗后的中医症候总积分、FBG、2h PG、Hb A1C、Cys C、Hcy、Scr、BUN水平均明显低于对照组(P<0.05)。观察组治疗的总有效率明显高于对照组(P<0.05)。结论:红花黄色素联合贝那普利治疗能够较好地改善早期糖尿病肾病患者的肾功能,值得临床推广。

Objective： To study the effect of soffor yellow combined with benazepril on the kidney function for patients with early diabetic nephropathy. Methods： 120 patients with early diabetic nephropathy admitted in our hospital from Jan 2014 to Aug 2014 were randomized into the control group （soffor yellow） attd the observation group （soffor yellow combined with beuazepril）, 60 patients per group. The TCM syndrome changes on pre- and post-treatment and clinical efficacy, the level changes of serum CysC, Hcy, Scr and BUN, and fasting blood-glucose （FBG）, two hours after a meal blood sugar （2h PG）, glycated hemoglobin （HbA1C） in the two groups were observed and compared. Results： Compared with pre-treatment, the TCM syndromes socres and the leves of FBF, 2hPG, HbA1 C, Cys C, Hcy, Scr, BUN were significantly reduced on post-treatment in both groups （P〈0.05）; compared with the control group, the TCM syndromes socres and the leves of FBF, 2hPG, HbA1C, Cys C, Hcy, Scr, BUN were significantly reduced in the observation group on post-treatment （P〈0.05）; compared with the control group, the total effective rate was significantly increased in the observation group （P〈0.05）. Conclusions： The treatment of soffor yellow combined with benazepril could better improve the kidney function of patients with early diabetic nephropathy and was worthy of clinical promotion.