天麻素对全麻宫颈癌根治术患者术后认知功能及S-100β影响

Influence of Cognitive Function and S-100 of Patients with Cervical Cancer Under General Anesthesia by Gastrodin

目的:探讨天麻素对全身麻醉下宫颈癌根治术患者术后认知功能及S-100β的影响。方法:选取我院妇科收治的宫颈癌患者86例,随机数字表法分为两组,两组患者均在全身麻醉下行全子宫双附件切除联合盆腔淋巴结清扫术。对照组术后予以抗感染、肠外营养支持等常规术后治疗,实验组术后常规治疗的基础上加用天麻素注射液。两组患者分别于麻醉前、手术后6 h、1 d、3 d及7 d测定MMSE评分及血中S-100β水平。结果:两组患者全麻宫颈癌根治术后均出现中度认知障碍,MMSE评分较麻醉前下降,与对照组同期比较,实验组术后3天、7天MMES评分较高,差异具有统计学意义(P<0.05);两组患者宫颈癌根治术后血中S-100β蛋白水平升高,与对照组同期比较,实验组术后1 d、3 d与7d S-100β水平较低,差异具有统计学意义(P<0.05)。结论:天麻素能够明显改善全麻宫颈癌根治术患者术后认知功能障碍,降低S-100β蛋白水,提高术后恢复效果,对临床具有指导意义。

Objective： To investigate the effect of cognitive function and S-100 βof patients with cervical cancer under general anesthesia by gastrodin. Methods： 86 patients with cervical cancer were randomly divided into two groups. All the patients were treated with the general anesthesia and pelvic lymphadenectomy. The patients in the control group were given anti infection, nutritional support and routine postoperative treatment, while the patients in the experimental group were treated with gastrodin injection on the basis of the conventional treatment. Then the MMSE score and blood S-100 β leve were detected before anesthesia and after the operation for 6hours, 1 day and 3 days. Results： The two groups showed mild cognitive impairment after radical operation of cervical cancer, and MMSE score decreased than before（P〈0.05）; compared with the control group, the MMES score of experimental group were higher（P〈0.05）; The levels of S-100 β of the two groups increased after the operation（P〈0.05）; compared with the control group, the experiment was lower（P〈0.05）. Conclusion： Gastrodin can significantly improve cervical cancer after radical surgery under general anesthesia cognitive dysfunction, reduced blood S-100 βprotein in order to improve the postoperative recovery which has the clinical significance.