黄连素治疗室性期前收缩效果的系统评价

Systematic review of the effect of oral berberine on premature ventricualr contraction

目的系统评价口服黄连素治疗室性期前收缩（PVC）的效果。方法检索Pub Med、CENTRAL、EMbase、NTIS、CNKI、VIP、万方数据库和CBM中所有对比口服黄连素和抗心律失常药物（AADs）治疗室性期前收缩的临床随机对照试验（RCT）,同时追索纳入文献的参考文献,检索时限均为从建库至2014年5月。对符合质量标准的RCT进行系统评价和Meta分析。结果共纳入12个随机对照试验。Meta分析的结果显示：黄连素的有效性显著高于AADs[85%（530/627）比79%（444/561）;OR=1.47;95%CI：1.09-1.99;P〈0.05],GRADE系统推荐分级为低级;且黄连素的不良反应发生率显著低于AADs[11%（32/292）比21%（59/287）;OR=0.46;95%CI：0.29-0.75;P〈0.01],GRADE系统推荐分级为低级。结论与目前传统的抗心律失常药物相比,黄连素治疗室性期前收缩的效果更好,且不良反应发生率更低。

Objective To assess the curative effect of oral berberine on premature ventricualr contraction. Methods The Pub Med,CENTRAL,Embase,NTIS,CNKI,VIP,Wanfang Data and CBM were retrieved with computers for collecting randomized controlled trials（ RCT） about the comparison in the curative effect of oral berberine and antiarrhythmic drug（ AADs） published from database construction to May 2014. At the same time,the reference materials of included literature were retrieved manually. The eligible data of RCT that meets the standard of quality was given a systemic review and Meta-analysis.Results There were totally 12 RCT included. The results of Meta-analysis showed that the curative effect of oral berberine was statistically higher than that of AADs[85%（ 530 /627） versus 79%（ 444 /561）; OR = 1. 47; 95% CI,1. 09 - 1. 99; P〈0. 05],and the incidence of adverse reaction of berberine was significantly lower than that of AADs [11%（ 32 /292） versus 21%（ 59 /287）; OR = 0. 46; 95% CI,0. 29 ~ 0. 75; P〈0. 01],which was recommended for low grade by GRADE system.Conclusion Compared with the traditional antiarrhythmic drugs,berberine is better for premature ventricualr contraction,and the incidence of adverse reaction of berberine is less.