2000—2014年中国40岁以上成人慢性阻塞性肺疾病患病率的Meta分析

Prevalence of COPD among Chinese people aged 40 years and over from 2000 to 2014:A Meta-analysis

目的：探讨2000—2014年我国40岁以上成人慢性阻塞性肺疾病（COPD）的患病状况和分布特征,阐明COPD患病的高危人群。方法：计算机检索PubMed、EMbase、维普（VIP）数据库、中国学术文献总库（CNKI）和万方数据库等中、英文数据库公开发表的有关我国40岁以上人群COPD患病率的文献,根据文献纳入和排除标准提取资料,并进行质量评价,采用Stata12.0软件对纳入的文献进行粗患病率和不同亚组患病率的Meta分析。结果：最终纳入文献49篇,共调查118 233人,患病10 819例。40岁以上成人COPD患病率为9.3%（95%CI：8.4%-10.1%）;男性COPD患病率为（12.5%,95%CI：11.2%-13.8%）,高于女性（6.1%,95%CI：5.3-6.8）;年龄越大,COPD患病率越高;学历越高,COPD患病率越低;近几年COPD患病率有所下降;农村人群COPD患病率为（10.2%,95%CI：9.3-11.2）,高于城市人群（7.9%,95%CI：6.8-9.0）;吸烟人群COPD患病率为（15.7%,95%CI：13.4-18.1）,高于非吸烟人群（5.4%,95%CI：4.5-6.3）;男性人群COPD患病率以华北地区（15.8%,95%CI：10.9-20.7）最高,女性则以东北地区（6.9%,95%CI：5.0-8.9）最高。结论：我国COPD患病率较高,不同特征群体患病率不同,男性、高年龄者、低学历者、吸烟人群和农村人群是COPD的高危人群。

Objective To investigate the prevalence and distribution characteristics of chronic obstructive pulmonary disease（COPD）in the adults aged 40 years and over in China,and to clarify the high risk population of COPD.Methods All published studies from PubMed,EMbase,VIP,CNKI,and Wanfang databases about COPD in Chinese or English were selected.According to the exclusion and inclusive criteria,the studies were selected,and the qualities of included studies were evaluated and the Meta-analysis was performed by Stata 12.0software.Results A total of 49 studies were included in this study.The total number of participants investigated was 118233,including 10 819 patients with COPD.The prevalence of COPD in the adults aged 40 years and over in China was 9.3%（95%CI：8.4%-10.1%）.The prevalence of COPD in men（12.5%,95%CI：11.2%-13.8%）was higher than that in women（6.1%,95%CI：5.3-6.8）.The older the age was,the higher the prevalence of COPD was.The higher the education was,the lower the prevalence of COPD was.In recent years,the prevalence of COPD was decreased.The prevalence of COPD in rural area（10.2%,95% CI：9.3-11.2）was higher than that in urban area（7.9%,95% CI：6.8-9.0）.The prevalence of COPD of smokers（15.7%,95% CI：13.4-18.1）was higher than that of non smokers（5.4%,95% CI：4.5-6.3）.For male,the highest prevalence showed in north China which was 15.8%（95%CI：10.9-20.7）,while for women it was highest in northeast which was 6.9%（95%CI：5.0-8.9）.Conclusion The prevalence of COPD in our country is still high.The prevalence is different among people with different characteristics. Male,higher age,low education level,smoking and rural population are high risk population of COPD.