铜催化羟基化反应合成左旋多巴

Synthesis of Levodopa via Copper-catalyzed Hydroxylation

本文介绍了一种新的左旋多巴制备方法,即以L-酪氨酸为起始原料,经溴代反应制得3-溴-L-酪氨酸,再经无配体参与的铜离子催化羟基化反应制得左旋多巴,总收率约59%。

A new synthesis of levodopa from L-tyrosine was described. Levodopa was prepared from L-tyrosine by bromization to give 3-bromo-L-tyrosine, followed by the ligand-free copper-catalyzed hydroxylation with an overall yield about 59%.