不同检测器-顶空气相色谱法测定甲磺酸达比加群酯中的甲磺酸乙酯和甲磺酸异丙酯

Comparison on Different Detectors for the Determination of Ethyl and Isopropyl Methanesulfonate in Dabigatran Etexilate Mesylate by Headspace Gas Chromatography

建立了顶空气相色谱法(HS-GC)测定甲磺酸达比加群酯中的甲磺酸乙酯和甲磺酸异丙酯,对比研究了不同检测器,即氢火焰离子检测器(FID)、电子捕获检测器(ECD)和质谱检测器(MS),主要从灵敏度、空白干扰性和样品测定等方面进行详细比较与评价,以期为不同品种药物活性成分(APIs)中甲磺酸酯含量测定方法的建立提供参考。

Headspace GC methods with different detectors were established and compared for the determination of ethyl and isopropyl methanesulfonate in dabigatran etexilate mesylate, including FID, ECD and MS detectors. Detailed comparisons and evaluations were conducted mainly from the sensitivity, interference and sample determination, in order to provide a reference for the establishment of determination methods for methanesulfonates in different APIs.