失眠、抑郁及焦虑心理状况与原发性开角型青光眼的相关性

Disturbed sleep and psychosocial factors associated with primary openangle glaucoma patients

目的评价失眠、抑郁及焦虑心理状况与原发性开角型青光眼(primary open angle glaucoma,POAG)的相关性。方法 2014年1月至2015年1月搜集120例POAG患者及120例正常对照。两组对象进行匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)、抑郁自评量表(self-rating depression scale,SDS)及焦虑自评量表(self-rating anxiety scale,SAS)测评,对两组得分进行比较。同时,对POAG组中3种量表得分进行相关性分析及性别分析。结果 POAG组的失眠、抑郁与焦虑得分(7.43±0.35,45.42±9.87,49.61±12.24)明显高于正常对照组(4.16±0.28,35.49±9.18,40.31±13.08)(P=0.000)。把PSQI总分>7分、SAS得分≥45、SDS得分≥50作为界值,POAG组失眠、抑郁和焦虑症状阳性率分别为54.2%、53.3%和50.0%,明显高于对照组(17.5%,25.8%,21.7%),差异组有统计学意义(P<0.05)。POAG患者失眠与焦虑评分呈正相关(r=0.243,P<0.01),抑郁和焦虑评分呈正相关(r=0.516,P<0.01),而抑郁与失眠之间无相关性(r=-0.002,P=0.979)。POAG患者中女性较男性更容易失眠,差异有统计学意义(χ2=7.38,P<0.05)。结论POAG患者的失眠、抑郁与焦虑情绪可能与青光眼的发生发展具有一定的相关性。

Objective To assess the correlation between disturbed sleep, depression and anxiety and primary open angle glaucoma （POAG）. Methods A sample of 120 POAG patients and 120 normal controls were enrolled from Jan. 2014 to Jan. 2015. All the participants were asked to complete the following questionnaires： self-rating Pittsburgh sleep quality index （PSQI）, self-rating anxiety scale （SAS） and self-rating depression scale （SDS）. Scores of them were compared between the two groups. Meanwhile correlation analysis of SAS, SDS and PSQI as well as gender analysis in POAG patients was made. Results The scores of PSQI, SAS and SDS were significantly higher in POAG patients （7.43±0.35;45.42±9.87;49.61± 12.24） than in normal controls （4. 16±0.28, 35.49±9. 18, 40.31 ± 13.08 ） （P=0.000） . Taking scores of PSQI〉7, SAS ≥45 and SDS ≥50 as cut-offs, the prevalence of disturbed sleep, depression and anxiety in the POAG group （54.2%, 53.3%, 50.0%） was significantly higher than those in the control group （17.5%, 25.8%, 21.7%） （P=0. 000）. Correlation was found between disturbed sleep and anxiety （r = 0. 243, P〈 0.01）, as well as depression and anxiety（r = 0. 516, P〈0.01） in POAG group. But there was no correlation between disturbed sleep and depression（r = - 0. 002, P = 0. 979）. Female tended to having more disturbed sleep problems than males in POAG group （P〈0.05）. Conclusions Disturbed sleep, depression and anxiety may related to the developing of glaucoma in POAG patients.