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内蒙古汉族寻常型银屑病GJB2基因rs72474224位点检测

Detection of the polymorphisms of GJB2 gene rs72474224 in patients with psoriasis vulgaris
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摘要 目的:检测内蒙古汉族寻常型银屑病GJB2基因rs72474224位点的多态性。方法:提取294例寻常型银屑病患者及287名正常对照外周血DNA,利用PCR和连接酶检测反应检测GJB2基因rs72474224的多态性。结果:SNP rs72474224等位基因T在病例组和对照组中的频率分别为0.03571和0.01045,差异具有统计学意义(P=0.004267)。结论:GJB2基因多态性rs72474224可能与内蒙古汉族人群寻常型银屑病的易感性相关。 Objective: To detect the polymorphisms of GJB2 gene rs72474224 in patients with psoriasis vulgaris in Han population in Inner Mongolia. Methods:DNA was extracted from the peripheral blood of 294 patients and 287 controls. The polymorphisms of GJB2 gene rs72474224 were genotyped by PCR-based ligase detection reaction ( PCR-LDR) . Results:The genotype frequencies of T in patients and controls were 0.0357 and 0.01045, with a significant difference (P=0.004267). Conclusion: The polymorphism of GJB2 gene rs72474224 is associated with psoriasis vulgaris in Han population in Inner Mongolia.
出处 《中国麻风皮肤病杂志》 2015年第9期522-525,共4页 China Journal of Leprosy and Skin Diseases
基金 国家自然科学基金(编号:31160192) 内蒙古医科大学青年创新基金项目(编号:NY2011QN005) 内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(编号:201303057) 内蒙古自治区高等学校"青年科技英才支持计划"(编号:NJYT-14-B17)
关键词 寻常型银屑病 GJB2 psoriasis vulgaris GJB2
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参考文献10

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