直肠神经内分泌肿瘤的临床病理特征及诊治和预后分析

Study on clinical pathological characteristics of rectal neuroendocrine neoplasm and its diagnosis and prognosis

目的分析直肠神经内分泌肿瘤的临床病理特征,探讨其诊断和治疗方法的合理选择。方法回顾性分析2010年1月至2013年12月期间收治的33例直肠神经内分泌肿瘤患者的临床、病理资料,总结内镜下切除或手术切除等治疗方法的效果。结果临床表现以腹痛、腹胀最常见;内镜超声(EUS)检查发现病变大部分≤2 cm,呈黏膜下低回声占位,内部回声欠均匀,边界清晰。治疗方法主要是内镜切除或外科手术切除。33例随访6个月至3年,均无复发及死亡。结论直肠神经内分泌肿瘤采用EUS检查及免疫组织化学有助于提高诊断率并及时治疗,避免误诊漏诊。内镜切除和外科手术是主要治疗手段,具体方式应根据肿瘤的生物学特性选择。

Objective To analyze the clinical pathological characteristics of colorectal neuroendocrine neoplasm,and to explore its diag-nosis and rational treatment of this kind of neoplasm. Methods The clinical and pathological data of 33 patients with rectal neuroendocrine neo-plasm underwent endoscopic resection etc during January 2010 to December 2013 in this hospital were analyzed,in order . to know the effectiveness of endoscopic resection and surgical removal of rectal neuroendocrine neoplasm. Results The common clinical manifestations of this tumor were abdominal pain and abdominal distention. The endoscopic ultrasonography（EUS）of these patients showed the size of lesions mostly were 2 cm or less,with low homogeneous echoes and clear margin. The treatment for these lesions was mainly by endoscopic resection or surgical resection. Conclusion In order to raise the rate of early diagnosis of this kind of rectal tumor,the application of EUS and immuno - histochemical examina-tion is helpful in diagnosis of rectal neuroendocrine neoplasm and avoid misdiagnosis. The endoscopic resection or surgical resection is the main procedure for treatment of this disease.