肠外营养联合ω-3鱼油脂肪乳诱导缓解治疗克罗恩病的临床观察

Effects of treatment of parenteral nutrition combined with ω-3 fish oil fat emulsion in Crohn's disease

目的观察肠外营养联合ω-3鱼油脂肪乳诱导缓解治疗克罗恩病的临床疗效。方法选择58例活动性梗阻型克罗恩病患者,根据治疗方法的不同分为研究组(肠外营养联合ω-3鱼油脂肪乳注射液)和对照组(肠外营养联合糖皮质激素)。观察两组患者治疗时间和诱导缓解成功率。结果研究组ω-3鱼油脂肪乳治疗时间16.83±6.98 d,对照组糖皮质激素治疗时间17.98±7.36 d,两组治疗时间无统计学差异(P>0.05)。研究组诱导缓解成功25例,成功率86.2%;对照组诱导缓解成功19例,成功率65.5%。研究组诱导缓解成功率显著高于对照组(χ2=9.981,P<0.001)。结论肠外营养联合ω-3鱼油脂肪乳诱导缓解治疗克罗恩病,成功率高,安全有效。

Objective To investigate the effects of treatment of parenteral nutrition combined with ω - 3 fish oil fat emulsion in Crohn＇s disease. Methods Fifty - eight cases of active obstruction Crohn＇s disease were collected. According to the method of treatment,they were divid-ed into the study group（parenteral nutrition with ω - 3 fish oil fat emulsion injection）and the control group（parenteral nutrition combined with glucocorticosteroids）,and the effects were observed. Results In the study group with ω - 3 fish oil fat emulsion,treatment time was 16. 83 ± 6. 98 days and in the control group,glucocorticosteroids treatment time was 17. 98 ± 7. 36 days. There was no significant difference between the two groups. In study group,25 cases had successful remission induction,with the success rate of 86. 2% and 4 cases failed. In the control group,19 cases had successful remission induction,with the success rate of 65. 5% and 10 cases failed. There was significantly higher treatment success rate in study group（χ2 = 9. 981,P ﹤ 0. 001）. Conclusion ω - 3 fish oil fat emulsion combined with parenteral nutrition therapy had a high success rate for induction of remission in Crohn＇s disease,which is safe and effective.