二维大环网状结构的双(三环已基锡)二元酸酯的合成、结构及生物活性

Syntheses, Crystal Structures and Biological Activities of Bis(tricyclohexyltin)dicarboxylates with Macrocyclic Building 2D Network

三环己基氢氧化锡分别与辛二酸和壬二酸进行甲醇溶剂热反应,合成了2个双(三环已基锡)二元酸酯(CH2)n(CO2Sn Cy3)2[(n:6(1),7(2)],并用IR、1H和13C NMR、元素分析和X射线单晶衍射表征结构。化合物1、2均属单斜晶系,空间群分别为P21/n和P21/c,在化合物的晶体中,1通过Sn-O共价键,2通过Sn-O和Sn…O弱作用,分别形成了四锡核30元(1)和32元(2)二维大环网状结构。化合物1、2对人癌细胞Colo205、Hep G2、MCF-7、Hela、NCI-H460均具有良好的体外抑制活性,对S.Aureus、B.Subtilis、E.Coli和S.Typhi具有选择性的抑菌作用。

Two bis （tricyclohexyltin）dicarboxylate （CH2）n（CO2SnCy3）2 [（n：6（1）, 7（2）] have been synthesized by thereaction of suberic acid and azelaic acid with tricyclohexyltin hydroxide, respectively. The structures of the productswere confirmed by IR, 1H and 13C NMR, elemental analysis and X-ray diffraction. The complexes 1 and 2 belong tomonoclinie, space group P21/n and P21/c. A 2D network structure was formed by 30-membered or 32-memberedmaerocyclie tetratin species, which has been alternately connected through the Sn-O covalent bond or the Sn-Ocovalent bond and Sn...O weak interaction, respectively. The tests showed the two complexes displayed strong in vitroanti-tumor activity against five human tumor cell lines, Colo205, HepG2, MCF-7, Hela and NCI-H460 and hasselective antibacterial property for S. Aureus, B. Subtilis, E. Coli andS. Typhi. CCDC： 1047100,1; 1047101,2.