男性单相与双相抑郁症患者脑区比率低频振幅特征研究

Study on fractional amplitude of low-frequency fluctuation in male patients with unipolar and bipolar depression

目的 探讨中青年男性单相与双相抑郁症患者静息态下局部脑区活动比率低频振幅（fractional amplitude of low-frequency fluctuation,fALFF）特征的差异,以期找到区分两者的生物学标记.方法 男性单相与双相抑郁症患者各12例与11例年龄及受教育年限匹配的男性健康对照进行3.0T静息态功能磁共振扫描,计算全脑fALFF值并行统计分析.结果 三组fALFF值在右侧眶内侧额中回（6,33,-9;K=29）、左侧内侧额上回（-6,60,3;K=44）和左侧中央旁小叶（-3,-27,51;K=20）差异有统计学意义（P＜0.01,Alphasim矫正）;单相抑郁症组较对照组左侧前扣带回fALFF值增加;双相抑郁症组较对照组双侧内侧额上回和左侧扣带回中部fALFF值增加;单相抑郁症组右侧眶内侧额中回、右侧前扣带回及双侧内侧额上回fALFF值显著低于双相抑郁症组（均P＜0.05）.结论 男性单相与双相抑郁症患者在静息状态下存在脑区活动异常,且两者脑区活动的异常存在差异.

Objective To explore the characteristic differences of the fractional amplitude of low-frequency fluctuation （fALFF） feature of the spoutaneous neural activity between young male unipolar depression and bipolar depression patients,and determine the biological markers to distinguish the two disorders.Methods Twelve male unipolar depression,12 bipolar depression patients and 11 age and educated-matched healthy males underwent resting-state functional magnetic resonance imaging scanning at 3.0 Tesla.The whole brain＇ s fALFF were calculated and analyzed.Results The differences of the fALFF of the three groups had significant differences （P〈0.01,Alphasim） in the right orbital medial frontal gyrus （6,33,-9;K =29）,the left medial frontal gyrus （-6,60,3;K =44） and the left paracentral lobule （-3,-27,5 1;K =20）.The unipolar depression subjects had significantly higher fALFF compared with heahhy controls in the left anterior cingulate gyrus.The bipolar depression subjects had significantly higher fALFF compared with healthy controls in the bilateral medial frontal gyrus and the left middle cingulate gyrus.And the unipolar depression subjects had significantly lower fALFF compared with bipolar depression ones in the right orbital medial frontal gyrus,the right anterior cingulate gyrus and the bilateral medial frontal gyrus（all P〈0.05）.Conclusions Abnormalities exist in the brain regions in male with unipolar or bipolar depression patients in the resting state,and the abnormal regions are different.