影响TPF方案治疗下咽癌患者疗效的临床因素分析

Analysis of clinical factors for the efficacy of TPF in treating hypopharyngeal carcinoma

目的:应用TPF方案治疗下咽癌患者,探讨影响疗效的各种临床因素。方法:回顾性分析20例接受TPF方案治疗的下咽癌患者,化疗2个疗程后根据影像学评估疗效制定下一步治疗方案,并对临床分型、肿瘤生长方式、病理类型、肿瘤分期、淋巴结转移及年龄等临床资料进行总结,分析可能影响疗效的临床因素。结果:120例下咽癌患者经TPF方案治疗2个疗程后客观缓解率为65%。2在下咽癌患者中,TPF方案的疗效与临床分型、肿瘤生长方式、病理类型有显著相关;与肿瘤分期、淋巴结转移及年龄差异无统计学意义。结论:根据下咽癌临床分型、肿瘤生长方式、病理类型等临床因素,可以评估下咽癌对化疗的敏感性,为提出个体化治疗方案提供重要依据。

Objective：To summarize the clinical effect of TPF regimen in the treatment of hypopharyngeal carcinoma and explore various clinical factors affecting treatment efficacy. Method： The clinical data of 20 cases with hypopharyngeal carcinoma, who received TPF treatment, were analyzed retrospectively. After two courses of chemotherapy, based on radiographic outcomes, next treatment plan was developed. To sum up the clinical information, including the clinical type, patterns of tumor growth, pathologic type, tumor stage, lymph node metastasis, age and so on. To analyze possible influencing factors affecting curative effect. Result：（1）After 20 cases with hypopharyngeal carcinoma received two courses of TPF treatment, the effect was evaluated. Objective response rate was 65 %. （2）In patients with hypopharyngeal carcinoma, the efficacy of TPF therapy was significantly related to the clinical type, patterns of tumor growth and pathologic type; there was no statistical significance in tumor stage, lymph node metastasis and age. Conclusion：According to the clinical type, patterns of tumor growth and pathologic type of hypopharyngeal carcinoma, resistance to chemotherapy in hypopharyngeal carcinoma can be assessed, which provides important basis for designing individualized treatment plan.