霍山石斛提取物降血脂作用研究

Hypolipidemic Activity of the Extracts of Dendrobium huoshanense

[目的]研究霍山石斛提取物对大鼠血脂的影响。[方法]采用混合型高脂血症动物模型试验,通过测定3个不同剂量组受试样品喂养的大鼠与高脂对照组大鼠的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),并经过统计学分析判断不同组别之间是否存在显著性差异。[结果]与高脂对照组值相比,大鼠接受受试样品灌胃45 d后,各剂量组TC和LDL-C值均降低,且存在显著差异;3个剂量组TG值下降也均具有显著差异,3个剂量组HDL-C值与高脂对照组无显著差异。[结论]霍山石斛提取物有降血脂功能。

[ Objective ] To study hypolipidemic activity of the extracts of Dendrobium huoshanense. [ Method ] Based on model experiments of animals with combined hyperlipidemia, rats were treated with three different doses of the water extract of Dendrobium huoshanense, with high fat group as control trial. The values of TC, TG, LDL-C and HDL-C in serum were determined and analyzed statistically by SPSS. [ Result] Compared with high fat control trial, the TC, TG and LDL-C in serum were brought down, after the treatment by the water extract ofDendrobium huoshanense for 45 days, significant difference with dose were detected by SPSS analysis. All the treatments showed negligible effects on the HDL- C value. [ Conclusion ] The extracts of Dendrobium huoshanense demonstrated obvious hypolipidemie activity.