miR-150在造血发育中的功能研究

The function of miR-150 in hematopoietic development

miR-150是一个在哺乳动物中表达的含22个核苷酸的miRNA,能通过抑制靶基因的翻译来调控细胞增殖、分化和凋亡等重要的生理、病理过程。miR-150的表达水平在造血发育不同谱系和不同阶段都存在明显差异,而造血发育异常也同样伴随着miR-150的表达异常,提示miR-150能够调控机体造血发育过程,参与了造血发育异常的发生。在机体造血系统中,miR-150主要通过调控其靶基因的表达来影响造血发育过程以及各谱系细胞的成熟、活化与功能效应。目前已报道的miR-150靶分子主要有c-Myb、Notch3、GAB1、FOXP1、Cxcr4、Prf1等。现就近年来miR-150在造血发育过程中的研究作一综述。

miR-150 is a kind of miRNA which has a length of 22 nucleotides and expresses in mammals, miR-150 participates in the regulation of cell proliferation, differentiation, apoptosis and other biological processes by inhibiting its target genes. During hematopoiesis, the expression of miR-150 is significantly distinct from different lineages and stages. Furthermore, the hematopoietic disorders also show an abnormal expression profile of miR- 150. All the evidences indicated that miR-150 can regulate normal and malignant hematopoiesis, and a lot of researches have showed that miR-150 involves in hematopoiesis and the maturation, activation, and function of different hematopoietic lineages mostly through its target genes such as c-Myb, Notch3, GAB 1, FOXP 1, Cxcr4, and Prfl. Here, the recent research progress of miR-150 in hematopoiesis is summarized.