摘要
针对深部肿瘤光动力治疗(PDT)过程中关键参数的采集,我们开发了一套实时在体的氧分压和微弱荧光监测及成像系统。该系统利用普林斯顿高灵敏度CCD采集微弱荧光图像,利用海洋光学氧传感器Neo Fox监测氧含量,采用Lab VIEW开发上位机控制程序,将荧光图像、氧分压、荧光强度数据、结果的显示、分析与存储等功能结合在一起,实现了光动力治疗过程中实时多参数监测与成像。经光动力治疗反应荧光实验,验证了系统的有效性,为后续PDT疗效评估研究工作奠定了基础。
Since the key multiple parameters need to be monitored during the photodynamic therapy( PDT) in deep tumor,we developed a pO2 and weak fluorescence monitoring and imaging system. The Princeton Instrument scientific- grade CCD was used as the fluorescence imaging detector,NeoFox of Ocean Optics as O2 sensor and LabVIEW as programming platform. The function of the system included the fluorescence image measurement,the pO2 data acquisition,the fluorescence intensity detection,result display,data analyzing and recording simultaneously. The system realized the real- time multiple parameters measurement and analysis during PDT.The PDT chemical reaction experiments validate the sensitivity of system,which has a potential for assessment of PDT.
出处
《生物医学工程研究》
北大核心
2015年第3期139-143,共5页
Journal Of Biomedical Engineering Research
基金
国家自然科学基金资助项目(61378092
61275199)
中央高校基本科研业务费专项资金资助项目(NP2015201
NS2015032)
中央高校基本科研业务费专项资金资助江苏省研究生培养创新工程项目(SJLX_0140)
关键词
光动力治疗
氧分压
微弱荧光成像
实时监测
疗效评估
Photodynamic therapy(PDT)
Partial pressure of oxygen
Weak fluorescence imaging
real-time monitor
Therapy evaluation