贝那普利联合地尔硫卓治疗老年高血压的疗效和安全性观察

Efficacy and Safety of Benazepril Combined with Diltiazem in Elderly Hypertention Treatment

目的观察贝那普利联合地尔硫卓治疗老年高血的临床疗效和安全性。方法入选老年原发性高血压患者100例,随机分为对照组(50例)和观察组(50例)。对照组采用贝那普利降压治疗,观察组采用贝那普利联合地尔硫卓降压治疗,疗程8周,每2周随访1次,观察收缩压、舒张压、心率、显效率、有效率、总有效率、降压达标率及不良反应。结果与对照组比较,8周后观察组收缩压、舒张压、心率较低,显效率、总有效率及降压达标率较高,差异有统计学意义(P<0.05);不良反应两组差异无统计学意义(P>0.05)。结论贝那普利联合地尔硫卓能显著降低老年高血压患者的血压,耐受性良好,不良反应少。

Objective To observe the clinical efficacy and safety of benazepril combined with diltialzem in elderly hypertention treatment. Method 100 elderly patients with essential hypertension were enrolled and randomly divided into control group（50 cases） and observation group（50 cases）. The control group were treated by benazepril, and the observation group were treated by Benazepril combined with diltiazem. Systolic and diastolic blood pressure, heart rate, explicit efficiency, efficiency, total efficiency, antihypertensive compliance rate and adverse reactions were observed by follow-up one every two weeks. Result Compared with the control group, systolic and diastolic blood pressure, heart rate were lower, explicit efficiency, total efficiency and antihypertensive compliance rate were higher in observation group after 8 weeks, the difference was statistically significant（p〈0.05）. Adverse reactions between two groups were not statistically significant（p〈0.05）. Conclusion Benazepril combined with Diltiazem can significantly reduce blood pressure, be well tolerated, and is fewer adverse reactions for elderly hypertensive patients.