妇科恶性肿瘤术后深静脉血栓形成患者组织因子及其途径抑制物的检测及意义

Detection and Significance of Tissue Factor and Tissue Factor Pathway Inhibitor of Gynecological Malignant Tumor Patients with Postoperative Deep Vein Thrombosis

目的通过对妇科恶性肿瘤术后下肢深静脉血栓形成患者血浆中组织因子(TF)、组织因子途径抑制物(TFPI)水平的变化,探讨其与妇科恶性肿瘤术后对深静脉血栓形成的影响。方法选择行妇科恶性肿瘤手术的患者62例,对照组20例为同期健康体检者,用酶联免疫吸附法检测TF,TFPI水平。结果妇科恶性肿瘤患者术后发生深静脉血栓8例,发生于子宫颈癌3例,子宫内膜癌3例,卵巢癌2例。TF,TFPI含量及活性对照组与3种妇科肿瘤比较差异均非常显著(P<0.01),TF有血栓形成妇科肿瘤组与无血栓组比较差异亦非常显著(P<0.01),TFPI指标两组差异有显著性(P<0.05)。结论妇科肿瘤患者术后血浆TF,TFPI水平升高更易诱发深静脉血栓形成。

Objective Through changes of gynecological malignant tumor in postoperative patients with lower extremity deep vein thrombosis plasma tissue factor （ TF） and tissue factor pathway inhibitor （ TFPI） level,to discuss its effect with gynecologic malignant tumor for postoperative deep vein thrombosis .Methods Sixty-two cases of patients with gynecological malignant tumor surgery were selected ,control group contained 20 cases of healthy check-up for the same period,enzyme linked immunosorbent method was used to detect TF ,TFPI level. Results Eight cases of gynecological malignant tumor patients with deep vein thrombosis occurred ,3 cases occurred in cervical cancer ,3 ca-ses occurred in endometrial carcinoma and 2 cases occurred in ovarian cancer .TF and TFPI content and activity of the control group compared with three kinds of gynecological tumors differences were very significant （P〈0.01）,TF thrombosis gynecological tumor group was also sig-nificantly different compared with no thrombus group （P〈0.01）,significant difference of index of TFPI was found in two groups （P〈0.05）. Conclusion Gynecology tumor patients postoperative plasma TF and TFPI levels are more likely to induce deep vein thrombosis .