慢性阻塞性肺疾病并肺动脉高压患者呼出气冷凝液中ET-1检测临床意义

The clinical significance of ET-1 detection in exhaled breath condensate frompatients with chronic obstructive pulmonary disease and pulmonary hypertension

目的探讨慢性阻塞性肺疾病(COPD)患者呼出气冷凝液(EBC)中内皮素-1(ET-1)水平与COPD合并肺动脉高压的关系。方法检测83例COPD患者EBC中ET-1水平,同期应用心脏超声测定所有研究对象的肺动脉压,按是否存在肺动脉高压再将83例患者分为单纯COPD组和COPD合并肺动脉高压组,比较两组研究对象的EBC中ET-1水平,并将ET-1与肺动脉压进行相关分析。结果 83例COPD患者经检测有36例存在肺动脉高压。COPD合并肺动脉高压组ET-1水平明显高于单纯COPD组(P<0.05)。COPD合并肺动脉高压组肺动脉压与ET-1水平呈正相关(r=0.573,P<0.05)。结论EBC中ET-1可能与COPD并肺动脉高压形成有关,EBC中ET-1可在一定程度上反映肺动脉压水平。

Objective To investigate the relationship between the levels of endothelin- 1（ ET- 1） in exhaled breath condensate（ EBC） and chronic obstructive pulmonary disease（ COPD） and pulmonary hypertension. Methods ET- 1 levels in EBC were detected in 83 cases of COPD patients andthe pulmonary artery pressure in all subjects were measured by echocardiography. The 83 patients were divided into two groups according to whether they with pulmonary hypertension. Compared the ET- 1 levels in EBC in two groups and analyzed the correlation between ET- 1 and pulmonary arterial pressure. Results There were 36 patients were proved to have pulmonary hypertension in the 83 patients. ET- 1 levels in pulmonary hypertension group were significantly higher than those in patients without pulmonary hypertension（ P〈0. 05）. The levels of ET- 1were correlated with pulmonary artery pressure in pulmonary hypertension group（ r = 0. 573,P〈0. 05）. Conclusions ET- 1 in EBC may be associated with COPD and pulmonary hypertension formation,ET- 1 in EBC mayreflect the level of pulmonary artery pressureto some extent.