加味抑肝汤与百忧解治疗抑郁症的对照观察

Treating depression with the Jiawei Yigan decoction plus Fluoxetine

目的:观察中药加味抑肝汤治疗抑郁症的临床疗效和不良反应。方法:采用随机对照试验,共纳入治疗组(加味抑肝汤)46例,对照组(百忧解)46例,于用药前及用药后第1、2、4、6周分别以汉密尔顿抑郁量表(24项,HAMD)评定药物疗效,用描述性记录不良反应。结果治疗6周后,治疗组和对照组有效率分别为76.1%和73.9%,差异无统计学意义(P>0.05);HAMD减分率治疗组与对照组差异无统计学意义(P>0.05)。不良反应发生率治疗组和对照组分别为15.2%和47.8%,差异具有统计学意义(P<0.01)。结论:加味抑肝汤治疗抑郁症与百忧解疗效相当,不良反应明显少于百忧解。

Objective To observe clinical efficacy and adverse reaction（ADR） of the Jiawei Yigan decoction on depression. Methods： patients were divided into two groups randomly： 46 cases in treatment group（Jiawei Yigan Decoction） and 46 cases in control group（Fluoxetine）, Hamilton Depression scale（24 Items, HAMD） was used to evaluate the drug effect, and the score was recorded at pre-drug treatment and 1, 2, 4, 6 weeks post-drug treatment. The discription of ADR was recorded in time. Results： After 6 weeks of treatment, the efficacy was 76.1% and 73.9% in treatment and control group respectively. There was no significant difference between two groups at efficiency（P〈0.05）, as well as at decreasing of HAMD（P〈0.05）. The incidence of ADR was 15.2% and 47.8%, respectively, there was statistical difference between two groups（P〈0.05）. Conclusion： The Jiawei Yigan Decoction show equivalent efficacy to Fluoxetine for despression, but causes less ADR.