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生物钟基因与血液系统恶性疾病 被引量：1

Progress of CLOCK genes in hematoligic malignancies
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摘要 生物钟是机体的一种内生的时间维持系统,广泛存在于各种机体内,表现在代谢、细胞增殖、生理和行为等各个方面。大量的流行病学研究证实,生理节律的改变,可以引起多种恶性肿瘤的高风险发病。近年来,随着对生物钟基因的研究发现。 Summary The CLOCK genes play a key role in the occurrence and development of many cancers. Similarly, CLOCK genes are also involved in hematologic malignancies. Changed circadian rhythms can affect hematopoiesis, causing abnormalities of the blood system. And the aberrant expression of CLOCK genes can be found in many hematologic malignancies. Taking into account of circadian rhyrhm in treatment of malignancies, can not only shorten the course of treatment, reduce complications,hut also prolong survival.
作者 原琳 周晋
机构地区 哈尔滨医科大学附属第一医院血液内科
出处 《临床血液学杂志》 CAS 2015年第5期826-828,共3页 Journal of Clinical Hematology
关键词 恶性血液病 生物钟基因 表达异常 hematologic malignancies CLOCK gene aberrant expression
分类号 R559 [医药卫生—血液循环系统疾病]
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参考文献24

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同被引文献11

  • 1Kelleher FC, Rao A, Maguire A. Circadian molecular clocks and cancer[ J]. Cancer Lett, 2014,342( 1 ) :9-18.
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  • 7Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock[J]. Hum Mol Genet, 2006,15(2) :R271-277.
  • 8Yang MY, Chang JG, Lin PM, et al. Downregulation of circadian clock genes in chronic myeloid leukemia: alternative methylation pattern of hPER3 [ J ]. Cancer Sci, 2006,97 ( 12 ) : 1298-1307.
  • 9Gery S, Gombart AF, Yi WS, et al. Transcription profiling of C/ EBP targets identifies Per2 as a gene implicated in myeloid leuke- mia[J]. Blood, 2005,106(8) :2827-2836.
  • 10I-Ianoun M, Eisele L, Suzuki M, et al. Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia[ J]. PLoS One, 2012,7 (3) : e34347.

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临床血液学杂志
2015年 第5期

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