动态高压微射流技术制备脂质体的研究进展

Research Progress on Liposome Preparation Using Dynamic High Pressure Micro-fluidization

传统方法制备的脂质体存在粒径大、包封率低、分散不均匀、有机试剂残留等问题。动态高压微射流技术是一种新兴的脂质体制备技术,结合了高压射流技术、撞击流技术和传统高压均质技术的优点,可弥补传统方法制备脂质体的缺陷,为实现工业化生产小粒径、高包封率、食用安全的脂质体提供了基础技术支撑。概述了脂质体制备技术、动态高压微射流法制备脂质体的优缺点以及动态高压微射流技术在脂质体制备中的应用,旨在为脂质体的工业化生产提供技术参考。

The liposomes prepared by traditional method has problems such as large particle size,low encapsulation efficiency,distribution uneven,and many organic reagent residues etc. Dynamic high pressure microfluidization（ DHPM） is a new kind of liposome preparation technology,which combines the advantages of water jet technology,impinging stream technology and the tranditional high pressure homogenization technology. DHPM can remedy the defect of traditional liposome preparation method, and provide basic technical support for realizing industrial production of liposomes with small particle size,high encapsulation efficiency,and edible safety. This paper brievely introdued the liposome preparative technique,the application of DHPM in liposome preparation,and the advantages and disadvantages of DHPM,aiming to provide technical reference for liposome industrilized production.