摘要沉默信息调节因子1（silent information regulator2，SIRT1）是具有烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide，NAD＋）依赖性的蛋白脱乙酰基酶，可作用于组蛋白和多种非组蛋白，发挥抗炎、抗凋亡、抑制氧化应激损伤、细胞衰老等多种生理病理过程。
2Imai S, Guarente L. Ten years of NAD-dependent SIR2 family deaeety- lases :implications for metabolic diseases[J]. Trends Pharmacol Sci, 2010, 31(5) :212-220.
3Vane I,Alvarez-Barrientos A,Arza E,et al. PGC-lalpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells[J]. Cardiovase Res, 2005,66 (3) : 562-573.
4Audrito V, Vaisitti T, Rossi D, et al. Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through acti- vation of the p53/miR-34alSIRT1 tumor suppressor network [J]. Cancer Res,2011,71 (13) :4473-4483.
5Giannakou ME ,Partridge L. The interaction between FOXO and SIRT1 : tipping the balance towards survival[J]. Trends Cell Bio1,2004,14 (8): 408-412.
6Kume S, Uzu T, Horiike K,et al. Calorie restriction enhances cell adapta- tion to hypoxia through Sirtl-dependent mitochondrial autophagy in mouse aged kidney[J]. J Clin Invest ,2010,120(4) : 1043-1055.
7Lee JH,Song MY,Song EK,et al. Overexpression of SIRT1 protects pan- creatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway[J]. Diabetes, 2009,58 (2) : 344-351.
8Bordone L, Motta MC, Picard F, et al. Sirt 1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells[J]. PLoS Biol,2006,4 (2) :e31.
9Kitada M, Koya D. SIRT1 in type 2 diabetes : mechanisms and therapeutic potential[J]. Diabetes Metab J, 2013,37 (5) : 315-325.
10Kitada M, Kume S, Kanasaki K, et al. Sirtuins as possible drug targets in type 2 diabetes[J]. Curr Drug Targets, 2013,14 (6) : 622-636.
