分析及预测治愈艾滋病的策略

Strategies for human immunodeficiency virus cure:current status and future prospects

抗反转录病毒联合疗法(cART)虽然能控制艾滋病病程,延长患者生命,但需长期用药,停药后会出现人类免疫缺陷病毒(HIV)反弹。体内HIV潜伏库细胞是造成病毒反弹的主要因素,围绕该潜伏库的研究发展出了多种艾滋病治愈的概念和策略。本文聚焦当前国际前沿,介绍一些具有重要发展前景的艾滋病治愈策略,并预测其未来的发展方向。

The combined antiretroviral therapy （cART） has been applied to control the course of human immunodeficiency virus （HIV） infection and acquired immunodeficiency syndrome （AIDS）. However, cART requires life-long daily treatment and strict adherence. HIV can quickly rebound after drug withdrawal because of the presence of the latent HIV reservoir in vivo. Therefore, reactivation of latent HIV and elimination of latent HIV reservoir are critical for cure of HIV infection and AIDS. Here, we review the recent advancements and future prospects on the strategies for HIV cure.