NKD1和APC在乳腺癌组织中的表达及意义

Expression and Significance on Expressions of NKD1 and APC in Breast Carcinoma

目的检测裸角质膜同源蛋白(NKD1)和结肠腺瘤性息肉病基因(adenomatouspolyposis coli,APC)在乳腺癌组织中的表达情况,探讨其临床意义及两者之间的相关性。方法选取75例乳腺癌患者的癌组织标本及其对应的距乳腺癌组织5 cm以上的正常乳腺组织作为对照,应用免疫组织化学染色方法检测NKD1和APC的表达情况,并分析其与乳腺癌病理特征间的关系以及两者之间的相关性。结果 NKD1和APC在正常乳腺组织中的表达阳性率明显高于乳腺癌组织(82.67%比36.00%;89.33%比45.33%),其差异有统计学意义(P<0.05);NKD1的表达与乳腺癌患者的年龄无关(P>0.05),而与其分化程度、TNM分期、淋巴结转移及远处脏器转移有关(P<0.05);APC的表达与患者年龄、乳腺癌的分化程度和淋巴结转移无关(P>0.05),而与其TNM分期及远处脏器转移有关(P<0.05)。NKD1和APC在乳腺癌组织中的表达呈正相关关系(r=0.609,P<0.05)。结论 NKD1和APC可能参与了乳腺癌的发生发展及远处脏器转移,并且两者可能在乳腺癌进展中存在着协同作用。

Objective To detect the expressions of NKD1 and APC in breast carcinoma tissues and to explore the clinical significance of their existence and their correlation. Methods The study selected 75 patients with breast carcinoma as the observation group, and their corresponding normal breast tissues from the breast carcinoma tissues more than 5 cm as the control group. The expressions of two proteins were detected by immunohistochemistry. Their relationship with the pathological characteristics of breast carcinoma and the correlation of the two proteins were analyzed. Results The positive expression rates of NKD1 and APC in normal breast tissues were significant1 higher than those in breast carcinoma tissues （82.67% vs. 36.00%, 89.33% vs. 45.33%, P〈0.05）. The expression of NKD1 was not correlated with the age of patients with breast carcinoma （P〉0.05）, while correlated with the degree of differentiation, TNM stage, lymph node metastasis, and remote organ metastasis of breast carcinoma （P〈0.05）. The expression of APC was not correlated with the age of patients with breast carcinoma, the degree of differentiation and lymph node metastasis of breast carcinoma （P〉0.05）, while correlated with the TNM stage and remote organ metastasis of breast carcinoma （P〈0.05）. The expressions of NKD1 and APC in breast carcinoma was positively correlated （r=0.609, P〈0.05）. Conclusion NKD1 and APC may be involved in the development and remote organ metastasis of breast carcinoma, and the two proteins may have a synergistic role in breast carcinoma.