慢加急性肝衰竭

Acute-on-Chronic Liver Failure

目的回顾分析有关慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)的研究进展,为ACLF的早期诊断、病情评估及治疗方案的选择提供参考。方法检索复习近年来国内外发表的有关ACLF的研究文献。结果 ACLF是慢性肝病基础上的急性损伤事件造成的肝功能失代偿临床症候群,为急性肝衰竭(acute liver failure,ALF)、亚急性肝衰竭(subacute liver failure,SALF)和慢性肝衰竭(chronic liver failure,CLF)之外的独立疾病。因其病情凶险、短期死亡率高和缺乏特效的治疗手段,故受到临床的广泛关注。结论对ACLF的研究取得较大的成果,但东西方国家仍存在争议;尽早发现其危险因素并结合临床实际早期采取综合的治疗措施,能够提高ACLF的总体生存率。

Objective To retrospective analysis the research progress of the acute-on-chronic liver failure （ACLF）, and provide some useful advice for the early diagnosis, evaluation, and treatments of ACLF. Methods The literatures on ACLF which published in domestic and overseas for these years were reviewed. Results ACLF, which is an acute deterioration of liver function results from precipitating events in patients with chronic liver disease. As an independent clinical entity and different from acute liver failure （ALF）, sub-acute liver failure （SALF）, and chronic liver failure （CLF）. For the high short-term mortality and seldom good treatment measures, attached much people＇s attention. Conclusion The research of ACLF makes great advance but still exits different in some field between the East and the West. Search dangerous etiolow~ earlier, combine with reality and early effective treatments can develop total survival rate of ACLF.