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microRNA与急性移植物抗宿主病研究进展

Advances in microRNA and graft-versus-host disease
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摘要 急性移植物抗宿主病（aGVHD）是异基因造血干细胞移植（allo-HSCT）后的常见并发症之一，重度aGVHD患者病死率高。HLA全相合患者allo-HSCT aGVHD发生率为40%～60%，HLA不全相合患者发生率更高［1］。aGVHD发病机制复杂，通常认为与免疫激活、炎症因子释放、细胞数量的改变和影响GVHD中的特定蛋白质水平有关。目前临床上诊断aGVHD主要根据临床特征及病理学证据，仍然缺乏监测、诊断aGVHD的生物标志物。最近，许多文献报道microRNA （miRNA）在aGVHD及肿瘤方面有重要作用。本文我们将miRNA在aGVHD中的研究进展进行综述。
作者 胡彬 黄斯勇 梁英民
机构地区 第四军医大学唐都医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2015年第10期894-896,共3页 Chinese Journal of Hematology
关键词 急性移植物抗宿主病 MICRORNA ALLO-HSCT 异基因造血干细胞移植 GVHD发生率 AGVHD MIRNA 临床特征
分类号 R457.7 [医药卫生—治疗学]
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参考文献29

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二级参考文献12

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中华血液学杂志
2015年 第10期

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