云南省首例人感染H5N6禽流感病例流行病学调查

Human infection with avian influenza A(H5N6) virus in Yunnan province: first case report

目的分析云南省首例人感染H5N6禽流感病例流行病学特征,为制定人禽流感防控措施提供依据。方法对人感染H5N6禽流感病例、密切接触者和感染来源进行流行病学调查,采集相关标本进行实验室检测,并应用描述性流行病学方法进行分析。结果病例确诊为人感染H5N6禽流感,临床表现主要为发热、咳痰、呼吸困难,胸片示双肺炎变,白细胞数目先下降后升高,因呼吸和循环衰竭死亡;病例有明确的野禽接触史,但感染来源不清晰,其密切接触者未发生H5N6禽流感传播;当地的活禽市场广泛存在禽流感病毒污染。结论云南省首次发现人禽流感病例,未发现人传人的证据。

Objective To analyze epidemiological characteristics of the first case of human infection with avian influenza A（H5N6） virus in Yunnan province and to provide evidences for control and prevention of the epidemic. Methods Epidemiological investigations on the infected case, close contacts and infection source were carried out; relevant specimens were collected and tested in laboratories. The data gathered were analyzed with descriptive epidemiology method. Results The case was diagnosed confirmedly as human infection with avian influenza A （ H5N6 ） virus in February 2015, with clinical manifestations of fever, expectoration, dyspnea, inflammatory condition of lungs by X-ray, lower number of white blood cell in early stage and ascending later, and died of respiratory and circulatory failure. The case had confirmed history of contacting with wild avian, but the infection source was not ascertained. There was no secondary case among the close contacts. Avian influenza A viruses contamination existed widely in local poultry markets. Conclusion The first case of human infection with avian influenza A in Yunnan province was reported and no evidence of human-tohuman transmission was identified.