针灸治疗失眠患者临床疗效观察及对炎症因子水平的影响

Clinical efficacy and impact on inflammatory cytokine levels in patients with insomnia acupuncture treatment

目的:探讨针灸治疗失眠患者临床疗效观察及对炎症因子水平的影响。方法:119例患者按照随机数字表法随机分为对照组(n=57)和治疗组(n=62)。对照组采用常规治疗方法,治疗组采用针灸治疗。两组患者均以10d为1疗程,连续治疗3个疗程。评价两组治疗疗效、治疗前后睡眠质量和炎症因子水平变化以及治疗期间不良反应发生情况。结果:治疗组治疗3个疗程后总有效率(88.71%)显著高于对照组(73.68%),且具有统计学差异(P<0.05);两组睡眠质量、睡眠时间、睡眠障碍、入睡时间、日间功能障碍、睡眠效率及PSQI量表总分治疗后较治疗前显著降低,且具有统计学差异(P<0.05);治疗组睡眠质量、睡眠时间、睡眠障碍、入睡时间、日间功能障碍、睡眠效率及PSQI量表总分治疗后显著低于对照组,且具有统计学差异(P<0.05);治疗组TNF-α、IL-6水平见治疗前显著降低,且具有统计学差异(P<0.05);两组间比较不具有统计学差异(P>0.05);两组均未见明显不良反应。结论:针灸治疗失眠患者临床疗效显著,可明显降低TNF-α、IL-6水平,从而延长睡眠时间。

Objective：To investigate the clinical efficacy of acupuncture treatment in patients with insomnia and its impact on levels of inflammatory cytokines.Methods：119cases of patients according to the random number table,randomly divided into a control group（n=57）and treatment group（n=62）.Control group with conventional therapy,the treatment group received acupuncture treatment.Two groups of patients were 10 dfor a course of treatment,continuous treatment of three courses.Evaluation of the efficacy of treatment in both groups before and after treatment and poor sleep quality and levels of inflammatory cytokines during treatment response were observed.Results：The treatment group after three courses of treatment efficiency（88.71%）was significantly higher（73.68%）,and had a statistically significant difference（P〈0.05）;two sleep quality,sleep duration,sleep disorders,sleep time daytime dysfunction,sleep efficiency and after treatment PSQI total score was significantly lower than before treatment,and had a statistically significant difference（P〈0.05）;treatment group,sleep quality,sleep duration,sleep disorders,sleep time and daytime function disorders,sleep efficiency and PSQI total score after treatment was significantly lower than the control group,and had a significant difference（P〈0.05）;Treatment group TNF-α,IL-6levels before treatment to see a significant reduction,and had a statistically significant difference（P〈0.05）;between the two groups was not statistically different（P〈0.05）;the two groups showed no significant adverse reactions.Conclusion：Acupuncture treatment of insomnia in patients with clinically significant effect,can significantly reduce TNF-α,IL-6levels,thus prolonging the sleep time.