鸦胆子油口服乳液联合放疗治疗食管癌效果观察

Effect of brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer

目的：探讨鸦胆子油口服乳液联合放疗治疗食管癌的疗效及患者不良反应。方法选取初治食管鳞状细胞癌患者50例，按随机数字表法分为观察组和对照组，各25例。所有患者均给予三维适形调强放疗，处方剂量95%计划靶区64 Gy，32次分割。观察组放疗同时给予鸦胆子油口服乳液，对照组仅单纯放疗。比较两组患者疗效、放疗反应及生活质量改善情况。结果观察组治疗有效率为92%（23／25），对照组为68%（17／25），两组差异有统计学意义（χ2＝4.500，P＝0.034）。观察组2级及以上放射性食管炎的发生率为20%（5／25），对照组为60%（15／25），两组差异有统计学意义（χ2＝8.333，P＝0.004）。观察组生命质量改善率为68%（17／25），对照组为40%（10／25），两组差异有统计学意义（χ2＝3.945，P＝0.047）。结论放疗联合鸦胆子油口服乳液治疗食管癌可提高疗效，减轻放疗反应，提高患者生命质量。

Objective To evaluate the efficacy and untoward effects of brucea javanica oil emulsion combined with radiotherapy in the treatment of patients with esophageal cancer. Methods 50 initial treatment patients with esophageal squamous cell carcinoma were randomly assigned to observation group （25 cases） and control group （25 cases）. All patients were treated with three dimensional conformal intensity modulated radiation therapy （3D-IMRT） and the radiation dose was 64 Gy/32 times （95 % PTV）. The patients in observation group received the treatment of brucea javanica oil emulsion during radiotherapy. The differences between the two groups were compared in respect of the efficacy, the adverse reactions and the quality of life （QOL）. Results The effective rate in observation group was 92%（23/25） and it was 68%（17/25） in control group, there was significant difference between the two groups （χ2 = 4.500, P= 0.034）. The incidence of radiation esophagitis at the level of RTOG2 and above in observation group was 20%（5/25） and it was 60%（15/25） in the control group, there was significant difference between the two groups （χ2= 8.333, P=0.004）. The improvement rate of QOL in observation group was 68 % （17/25） and it was 40 % （10/25） in control group, there was significant difference between the two groups （χ2 = 3.945, P= 0.047）. Conclusion Brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer can improve the therapeutic effect and QOL,it can also reduce radiation reactions.