IL-23/IL-17轴在强直性脊柱炎发病中的作用及治疗意义研究进展

Roles of IL-23/IL-17 axis in pathogenesis and treatment of ankylosing spondylitis

强直性脊柱炎(AS)发病机制至今不明,治疗效果不佳。白细胞介素(IL)-23/IL-17轴是近几年受到高度重视的重要免疫通路。本文对IL-23/IL-17轴在AS发病遗传学和免疫学中的作用进行论述,并介绍了抗IL-23和抗IL-17抗体用于治疗AS的新进展。IL-23/IL-17轴在AS发病和治疗中的重要作用提示其可能成为一个有效的新治疗靶点。

The treatments for ankylosing spondylitis （AS） are still not effective, which partially due to its unclear patho-genesis. Interleukin （IL）-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro-duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL-17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.