盐酸氨溴索联合布地奈德治疗小儿支气管肺炎的临床疗效及其对C反应蛋白和白细胞计数的影响

Clinical Effect of Ambroxol Hydrochloride Combined with Budesonide on Bronchial Pneumonia in Children and Its Impact on CRP and WBC

目的探究盐酸氨溴索联合布地奈德治疗小儿支气管肺炎的临床疗效及其对C反应蛋白(CRP)和白细胞计数(WBC)的影响。方法选取成都市第五人民医院2013年1月—2014年1月收治的支气管肺炎患儿100例,按照随机数字表法分为观察组和对照组,每组50例。对照组患儿给予常规治疗,观察组患儿在对照组基础上给予盐酸氨溴索联合布地奈德治疗,两组患儿均治疗14 d。比较两组患儿临床疗效,治疗前及治疗3 d、7 d、10 d、14 d血清CRP水平、WBC,观察不良反应情况。结果观察组患儿临床疗效优于对照组(u=2.33,P<0.05)。对照组与观察组患儿不同时间点血清CRP水平及WBC比较,差异有统计学意义(P<0.05);其中治疗方法与时间存在交互作用(P<0.05);组间比较,差异有统计学意义(P<0.05);不同时间间比较,差异有统计学意义(P<0.05)。对照组不良反应发生率为10.4%,观察组不良反应发生率为12.0%,差异无统计学意义(P>0.05)。结论盐酸氨溴索联合布地奈德治疗小儿支气管肺炎的临床疗效确切,能有效降低患儿血清CRP水平及WBC。

Objective To explore the clinical effect of ambroxol hydrochloride combined with budesonide on bronchial pneumonia in children and its impact on CRP and WBC. Methods A total of 100 children with bronchial pneumonia were selected in the Fifth People′s Hospital of Chengdu from January 2013 to January 2014 , and they were randomly divided into control group and observation group,50 cases in each. Children of both groups were given conventional treatment,while children of observation group were given extra ambroxol hydrochloride combined with budesonide,both groups treated for 14 days. Clinical effect,serum CRP level and WBC before treatment and after 3 days,7 days,10 days,14 days of treatment,incidence of adverse reactions were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group（u=2. 33,P〈0. 05）. There were significant differences of serum CRP level and WBC between control group and observation group at different time points（P〈0. 05）;there were interaction between treatment method and time（P〈0. 05）;the difference among groups showed statistically significantly different（P〈0. 05）;the difference among time points showed statistically significantly different（P〈0. 05）. The incidence of adverse reactions of control group was 10. 4%,that of observation group was 12. 0%, the difference was not statistically significant （ P〉0. 05 ）. Conclusion Ambroxol hydrochloride combined with budesonide has certain clinical effect in treating bronchial pneumonia in children,can effectively reduce the serum CRP level and WBC.