沙美特罗替卡松粉吸入剂联合戒烟干预治疗慢性阻塞性肺疾病的临床疗效及其对肺功能的影响

Clinical Effect of Salmeterol and Fluticas Powder Inhalant Combined with Smoking Cessation Intervention on Chronic Obstructive Pulmonary Disease and Its Impact on Lung Function

目的探究沙美特罗替卡松粉吸入剂联合戒烟干预治疗慢性阻塞性肺疾病(COPD)的临床疗效及其对肺功能的影响。方法选取乌鲁木齐巿第一人民医院2013年1月—2014年5月收治的64例COPD患者,均为男性,随机分为观察组和对照组,每组32例。两组患者均给予沙美特罗替卡松粉吸入剂治疗,观察组在此基础上行戒烟干预,两组患者均治疗6个月。比较两组患者临床疗效,治疗前后临床症状评分及肺功能指标〔第一秒用力呼气容积(FEV1)、一秒率(FEV1/FVC)〕。结果观察组患者有效率为93.8%,高于对照组的75.0%(P<0.05)。两组患者治疗前临床症状评分比较,差异无统计学意义(P>0.05);观察组患者治疗后临床症状评分低于对照组(P<0.05)。两组患者治疗前FEV1、FEV1/FVC比较,差异无统计学意义(P>0.05);观察组患者治疗后FEV1、FEV1/FVC高于对照组(P<0.05)。结论沙美特罗替卡松粉吸入剂联合戒烟干预治疗COPD的临床疗效确切,且能有效改善患者的肺功能。

Objective To observe the clinical effect of salmeterol and fluticas powder inhalant combined with smoking cessation intervention on chronic obstructive pulmonary disease and its impact on lung function. Methods A total of 64 male patients with chronic obstructive pulmonary disease were selected in the First People′s Hospital of Urumqi from January 2013 to May 2014,and they were randomly divided into control group and observation group,each of 32 cases. Patients of both groups received salmeterol and fluticas powder inhalant, while patients of observation group received extra smoking cessation intervention,both groups treated for 6 months. Clinical effect,clinical symptoms score and lung function index（ including FEV1 and FEV1/FVC） before and after treatment were compared between the two groups. Results The effective rate of observation group was 93. 8%, was statistically significantly higher than that of control group of 75. 0% （ P〈0. 05 ）. No statistically significant differences of clinical symptoms score was found between the two groups before treatment（P〉0. 05）,while clinical symptoms score of observation group was statistically significantly lower than that of control group after treatment（P〈0. 05）. No statistically significant differences of FEV1 or FEV1/FVC was found between the two groups before treatment（P〉0. 05）,while FEV1 and FEV1/FVC of observation group were statistically significantly higher than those of control group after treatment（ P〈0. 05）. Conclusion Salmeterol and fluticas powder inhalant combined with smoking cessation intervention has certain clinical effect in treating chronic obstructive pulmonary disease,can effectively improve the lung function.