异基因造血干细胞移植后嵌合状态的研究进展

Research progess of chimerism after allogeneic hematopoietic stem cell transplantation

异基因造血干细胞移植（allo—HSCT）为诸多血液系统疾病的重要治疗手段。受者接受allo—HSCT后，移植物排斥（GR）、原发疾病复发及移植物抗宿主病（GVHD）的发生影响allo—HSCT成功与否。动态监测供受者嵌合状态对于预测疾病转归、减少疾病复发具有重要意义。预处理方案、基础疾病、输入干细胞数量等多种因素均会影响受者嵌合状态的形成。不同形式的嵌合状态及其临床意义亦各不相同。笔者拟就上述几个方面对allo—HSCT后嵌合状态影响的研究进展进行综述。

Allogeneic hematopoietic stem cell transplantation （allo-HSCT） has become an important treatment for a lot of hematologic diseases. The success of allo-HSCT is affected by graft rejection （GR）, relapse of the original diseases or graft versus host disease （GVHD）. Sequential monitoring of chimerism is important for disease prognosis and reducing relapses of the original diseases. Conditioning regimen, underlying diseases, the amount of infused hematopoietic stem cells and other factors will affect the formation of chimerism. The clinical significance was different for various forms of chimerism. This article reviews literatures on recent advances in chimerism of aforementioned aspects.