艾滋病患者医院感染多药耐药菌监测分析

Surveillance of multidrug-resistant organisms causing nosocomial infections in AIDS patients

目的了解艾滋病患者医院感染多药耐药菌的易感细菌和易感部位等特点,为传染病医院的医院感染管理控制重点提供依据。方法选择2011-2014年医院感染患者279例,发生医院感染多药耐药菌的54例艾滋病患者进行总结,并与同期发生医院感染多药耐药菌的149例患者进行比较,分析艾滋病患者医院易感的多药耐药菌和感染部位。结果 2011-2014年279例医院感染患者发生多药耐药菌感染149例,多药耐药菌感染率53.41%;其中81例艾滋病医院感染患者发生多药耐药菌感染54例,多药耐药菌感染率66.67%,两组感染率比较,差异有统计学意义(P<0.01);艾滋病患者易感部位为血液系统,易感多药耐药菌为大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌,分别占25.93%、16.67%、16.67%。结论应加强重视艾滋病患者医院感染多药耐药菌的感染控制工作,以有效预防控制艾滋病患者医院感染多药耐药菌的发生。

OBJECTIVE To understand the susceptible multidrug‐resistant organisms （MDROs） causing nosocomial infections in the AIDS patients and susceptible infection sites so as to provide guidance for control of the nosocomi‐al infections in the infectious disease hospital .METHODS A total of 279 patients with nosocomial infections who were treated in the hospital from 2011 to 2014 were enrolled in the study ,54 AIDS patients with MDROs infec‐tions were observed and compared with 149 patients who had the MDROs infections during the same period .The susceptible MDROs causing infections and the infection sites were analyzed .RESULTS Of 279 patients with noso‐comial infections who were treated in the hospital from 2011 to 2014 ,149 had the MDROs infections ,with the in‐cidence of MDROs infections of 53 .41% .Of the 81 AIDS patients with nosocomial infections ,54 had the MDROs infections ,with the incidence of MDROs infections of 66 .67% ,and there was significant difference in the infection rate between the two groups （P〈 0 .01） .The blood system was the susceptible infection site of the AIDS pa‐tients .Escherichia coli ,Pseudomonas aeruginosa ,and K lebsiella pneumoniae were the susceptible MDROs ,ac‐counting for 25 .93% ,16 .67% ,and 16 .67% ,respectively .CONCLUSION It is necessary to focus on the control of the MDROs infections in the AIDS patients so as to effectively prevent the nosocomial infections in the AIDS pa‐tients .