146例喘息患儿Fcε RI-β基因多态性与临床表现和疗效相关性研究

Correlation between FcεRI-βgene polymorphisms and clinical manifestations and curative effect in wheezing infants

目的 通过检测146例喘息患儿FcεRI-β基因多态性与临床表现、药物疗效相关性的研究,探讨该基因多态性对喘息患儿的易感性与疗效的作用.方法 选取住院喘息患儿146例,用荧光定量PCR法检测患儿FcεRI-β基因,其中AG、GG为风险基因型,共41例,AA为正常基因型,共105例;记录两组患儿的喘息发作程度、检测肺功能;记录两组临床疗效（雾化治疗、全身使用糖皮质激素、住院时间、后续治疗）.结果 风险型基因组与正常型基因组在喘息发作严重程度中的分布差异有统计学意义,P=0.003,风险型基因组较正常型基因组喘息发作严重;两组患儿在肺功能异常上差异无统计学意义,P=0.53;两组在雾化治疗上差异无统计学意义,P=0.74;两组在使用全身糖皮质激素上差异无统计学意义,P=0.21;两组在住院时间上差异无统计学意义,P=0.21;两组患儿在后续治疗上差异无统计学意义,P=0.63.结论 FcεRI-β基因多态性与患儿的喘息发病相关,风险型基因是喘息发生的危险因素;风险型基因影响喘息发作的严重程度;但不是影响肺功能的主要因素;基因多态性不是影响疗效的主要因素.

Objective To investigate the correlation between FcεRI-βgene polymorphisms and the clinical manifestations and curative effect in wheezing infants.Methods 146 wheezing infants were recruited and divided into a risk genotype group （n=41） and a normal genotype group（n=105）.FcεRI-β was detected with PCR.The genotype distribution, clinical manifestations, lung function, and curative effect were analyzed and compared between the two groups.Results FcεR1-β E237G AG/GG was more serious than FcεR1 AA in wheezing infants （x 2=14.202, P=0.003）.There were no statistical differences in lung function, curative effect, glucocorticoid use,hospital stay, and subsequent treatment between these two groups （P〉0.05）.Conclusions FcεRI-βgene polymorphisms correlates with infantile wheezing.Risk genotype infects wheezing seriousness but isn＇t the main factor affecting lung function.FcεRI-βgene polymorphisms isn＇t the main factor affecting curative effect.