颞叶内侧癫癎患者血清SIOOB浓度的变化

The changes of the concentration of serum SIOOB in patients with temporal lobe epileps

目的：探讨颞叶内侧癫癎（mesialtemporallobeepilepsy，MTI。E）患者血清蛋白S100B的浓度变化；分析病例组中海马硬化组与非硬化组中S100B的差别，以探讨其是否与海马硬化程度有关。方法：利用ELISA法测定30例颞叶癫癎患者的血清蛋白S100B浓度，以同期在我院儿科就诊的上呼吸道感染和腹泻恢复期患者及体检中心体检的正常成人30例作为对照；根据患者MRI海马有无硬化分为两组，分析两组血清S100B的差别。结果：30例MTLE患者血清S100B浓度为（0．255±0．074）μg／L，与30例正常对照组（o．108±0．020）μg／L比较差异有统计学意义（P=0．001）；伴有海马硬化患者血清S100B（0．303士0．052）μg／L水平显著高于无海马硬化者（O．222±0．068）μg／L（P=0．002）。结论：S100B可能是MTLE的生物标志物，并可能反映海马硬化程度。

Objective： To investigate the chanfes of the concentration of serum S100B in patients with mesial temporal lobe epilepsy, and analyze the difference of serum S100B between MTLE-HS patients and MTLE patients without HS, in order to explove whether it is associated with the degree of hip- pocampal sclerosis. Methods：The conceutration of plasma S100B levels by ELISA was measured in 30 pa- tients with MTI.E and 30 healthy controls and their diffenences were analyzed. Results： The serum S100B levels in 30 patients with MTLE had siqnificant changes compared with healthy controls （P= 0. 001 ）. Moreover, S100B levels were significantly higher MTLE-HS patients than those MTI.E patients without HS （P=0. 002）. Conclusion：S100B may be a biomarker of MTLE, and may reflect the degree of hipp- ocampal sclerosis.