小泛素样修饰蛋白在缺血性脑损伤中研究进展

Research progress of small ubiquitin-like modifier in brain injury induced by cerebral ischemia

小泛素样修饰蛋白(small ubiquitin-like modifier,SUMO)是一组能与底物蛋白的赖氨酸残基发生共价结合的蛋白。在生理和病理条件下,SUMO可通过与不同底物蛋白的结合调节机体各种生物学过程。SUMO与底物蛋白结合的过程称为SUMO化,是可逆过程。脑缺血时脑组织中SUMO化水平明显升高,且在深低温和中度低温情况下SUMO化水平明显升高。这种缺血后激活的SUMO化被认为是一种内源性神经保护反应。本文对蛋白质的SUMO化修饰在缺血性脑损伤中的研究进展作一综述。

Small ubiquitin-like modifier （SUMO） is a group of proteins acting by covalent attachment to lysine residues on target proteins and thereby modulate various processes that plays important roles in key cellular functions under normal and pathological conditions. The process of SUMO conjugation is reversible. A number of recent publications have suggested that the SUMO conjugation of target proteins plays a role in the cellular response to ischemia and is markedly activated in the brain during deep to moderate hypothermia. The post-ischemic activation of SUMO conjugation is believed to be an endogenous neuroprotective stress response. This paper mainly reviews the updated novel roles of the SUMOylaiton in brain injury induced by cerebral ischemia.