福多司坦在肺结核患者祛痰治疗中的应用

Effect of fudosteine in treating pulmonary tuberculosis

目的探讨肺结核患者应用福多司坦片祛痰的疗效和安全性。方法选取2014年10月~2015年4月在某院住院治疗的肺结核患者60例,随机分为两组,福多司坦组30例在接受正规抗结核治疗基础上给予福多司坦片治疗,盐酸氨溴索组30例在接受正规抗结核治疗基础上给予盐酸氨溴索氯化钠注射液治疗,治疗7 d后评价患者痰液的粘稠度、咳痰难易、咳嗽程度及不良反应等情况。临床综合疗效用积分改善率来评价。结果盐酸氨溴索组、福多司坦组临床综合疗效积分改善率：痰液粘稠度90.48%、96.97%,咳嗽难易程度90.63%、94.12%,咳嗽程度91.04%、94.20%。两组痰液粘稠度、咳痰难易程度、咳嗽程度无明显差异（P〉0.05）。两组间不良反应发生率的差异无统计学意义（P〉0.05）。结论福多司坦在肺结核患者治疗中祛痰疗效确切,安全性较好,易于服用。

Objective To evaluate the therapeutic effect and safety of fudosteine in treating pulmonary tuberculosis. Methods 60 patients with pulmonary tuberculosis treated in the fourth hospital of Lianyungang in 2014 -2015 were randomly divided into two groups. All the patients were received anti- tuberculosis drugs. 30 patients in fudosteine group received fudostein. 30 patients in alllbroxol hydrochloride group received ambroxol hydrochloride. The main indicators included character of sputum, difficulty in expectoration and cough were compared and analyzed after 7 days. Results The character of sputum in fudosteine group and in the ambroxol hydrochloride group were 90.48% and 96.97% respectively. The character of difficulty in expectoration in the above- mentioned two groups were 90.63% and 94.12% respectively. The character of cough in the above-mentioned two groups were 91.04% and 94.20% respectively. There were no significant differences of curative effect in the two groups （P 〉 0.05）. There were no significant differences of drug adverse reaction in the two groups （P 〉 0.05）. Conclusion Fudosteine tablet may be a safe and effective phlegm eliminating drug. It is worth to widely applied to alleviate the symptoms of the pulmonary tuberculosis.