铝盐促进的谷氨酸转氨化合成α-酮戊二酸的研究

Aluminum(Ⅲ) Salts Promoted Transamination of Glutamic Acid for the Synthesis of α-Ketoglutaric Acid

报道了以铝盐为促进剂、通过对谷氨酸向乙醛酸水合物转氨化合成α-酮戊二酸的简便方法.通过对反应条件的系统优化,发现在少量简单铝盐KAl(SO4)2·12H2O存在下,在p H=5的水溶液中,80℃下反应4 h,能够方便地实现谷氨酸向乙醛酸的高效转氨化,α-酮戊二酸收率最高可达到87%.该方法原料价廉易得、操作简便、产率优良、提供了一种α-酮戊二酸的高效、实用合成方法.

This paper reports an efficient approach for the synthesis of α-ketoglutaric acid via Al（III） salt promoted transamination of glyoxylic acid monohydrate with glutamic acid. Under optimized conditions（80 ℃, pH=5）, the transamination proceeded efficiently in an aqueous solution of glyoxylic acid and glutamic acid in the presence of a catalytic amount of KAl（SO4）2·12H2O, affording α-ketoglutaric acid in up to 87% yield. This method features inexpensive chemical feedstocks, easy operation and high productivity, thus providing an efficient and practical approach to α-ketoglutaric acid.