前列地尔注射液致过敏性休克6例

Six Cases of Anaphylactic Shock Induced by Alprostadil Injection

目的：分析前列地尔注射液致过敏性休克的特点。方法：对2014年1~3月我院使用前列地尔注射液的1 624例患者进行药品不良反应监测,对其中发生过敏性休克的6例患者病例资料进行统计分析。结果：6例过敏性休克均发生在介入科,多发生在动脉插管时给药,两个批号药品发生率高。患者均出现血压急剧下降、胸闷、心慌、气喘、而色苍白、大汗淋漓等症状,经过抗过敏、升压、给氧等一系列治疗措施,生命体征逐步稳定。结论：前列地尔注射液致过敏性休克与动脉注射的给药方式有相关性,因此用药时应严密观察患者病情及生命体征变化,防止发生严重不良反应。

Objective： To analyze the feature of anaphylactic shock induced by alprostadil injection. Methods： Totally 1624 pa- tients treated with alprostadil injection in our hospital from January to March 2014 were undergone adverse drug reaction monitoring. Six cases of anaphylactic shock induced by alprostadil injection were statistically analyzed. Results： 6 cases of anaphylactic shock induced by alprostadil injection occurred in the department of intervention and most of thd reaction happened in arterial injection. Two lot num- ber of drugs were in high frequency. Patients showed a sharp fall in blood pressure, chest discomfor, palpitation, shortness of breath, paleness, sweating and other symptoms. After anti allergy, blood pressure, oxygen the rapy and other treatment measures vital signs gradully stabilized. Conclusion： Anaphylactic shock induced by alprostadil injection is in correlation with the administration mode of artery injection. The change of the patient＇ s condition and vital signs should be closely observed when we inject the patient with alprostadil injection. We must prevent the occurrence of serious adverse reactions.