mTOR在脂质稳态中的作用及运动调节

Functions of mTOR in Lipid Homeostasis and Exercise-Related Regulation

哺乳动物雷帕霉素靶蛋白(mechanistic or mammalian target of rapamycin,mTOR)信号通路可以整合营养、能量、生长因子、运动等多种细胞外信号,调节众多的代谢和生理过程,如基因转录、蛋白质翻译、核糖体合成、脂质稳态等。对近期mTOR脂质稳态调节的研究进行文献综述,着重综述mTOR在脂解、脂肪生成以及脂肪细胞形成中的重要作用,同时探讨运动对mTOR的作用效应。以期对将来研究运动通过mTOR影响脂质稳态提供理论支持、加深对脂质稳态变化引起的相关疾病的理解、促进更合理的运动处方建议以及靶向药物的研发提供帮助。

The mechanistic or mammalian target of rapamycin （roTOR） signahng pathway can integrate mumpie extracel- lular signals including nutrition, energy, growth factors and exercise to regulate numerous metabolic and physiological processes, such as gene transcription, protein translation, ribosome biogenesis and lipid homeostasis. This review ex- plores recent findings on the role of mTOR in lipid homeostasis, with an emphasis on lipolysis, lipogenesis, and adipogen- esis, also discusses the effects of exercise on mTOR. The purpose is to provide theoretical supports for future study on the effects of exercise on lipid homeostasis via mTOR, deepen understanding of lipid homeostasis related diseases, pro- mote more reasonable exercise prescriptions and targeted drug research and development.