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视神经脊髓炎动物模型及研究进展 被引量：5

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摘要 视神经脊髓炎（neuromyelitis optica,NMO）是一种具有复发缓解倾向、主要累及视神经和脊髓的中枢神经系统（central nervous system,CNS）炎性脱髓鞘疾病.NMO患者血清中存在一种特异性IgG抗体,即NMO-IgG,可与星形胶质细胞（astrocyte,AS）上的水通道蛋白4（aquaporin-4,AQP4）特异性结合,激发一系列异常免疫反应,导致疾病发生.NMO-IgG的发现支持NMO是一种独立于多发性硬化（multiple sclerosis,MS）的疾病.
作者 方羚 邱伟
机构地区 中山大学附属第三医院神经科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2015年第10期916-918,共3页 Chinese Journal of Neurology
关键词 视神经脊髓炎 动物模型 炎性脱髓鞘疾病 特异性IGG抗体 中枢神经系统 星形胶质细胞 异常免疫反应 水通道蛋白
分类号 R744.52 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献26

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二级参考文献26

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共引文献3

同被引文献45

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引证文献5

二级引证文献11

中华神经科杂志
2015年 第10期

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