原发韦氏环非霍奇金淋巴瘤50例临床特征和预后分析

Clinical characteristics and prognosis analysis of 50 patients with primary Waldeyer＇s ring non-Hodgkin lymphoma

目的比较原发韦氏环非霍奇金淋巴瘤（WRNHL）常见病理类型的临床特征与预后差异。方法对2008年1月至2013年12月收治的50例原发WRNHL患者的临床资料进行回顾性分析。Kaplan-Meier法计算生存率，用Log-rank法检验组间差异并行单因素预后分析。结果原发WRNHL常见病理类型为弥漫大B细胞淋巴瘤（DLBCL）与结外鼻型NK／T细胞淋巴瘤（ENKTCL），其中DLBCL占56％（28／50），ENKTCL占34％（17／50）。DLBCL的发病年龄明显大于ENKTCL，两者原发部位不同，50．0％（14／28）的DLBCL患者原发于扁桃体，88．2％（15／17）的ENKTCL原发于鼻咽部；DLBCL的近期疗效远优于ENKTCL，DLBCL的总生存率、无进展生存率均优于ENKTCL，差异均有统计学意义（χ2=4．45，P=0．035；χ2=6．47，P=0．011）。结论DLBCL和ENKTCL的临床特征不同，DLBCL的近期疗效及预后明显优于ENKTCL。

Objective To compare the clinicopathological characteristics and prognosis of primary Waldeyer＇s ring non-Hodgkin lymphoma. Methods From Jan 2008 to Dec 2013, 50 patients with primary Waldeyer＇s ring non-Hodgkin lymphoma were retrospectively analyzed. Kaplan-Meier method was used for survival analysis. Log-rank method was used for univariate analysis. Results Waldeyer＇s ring diffuse large B-cell lymphoma （DLBCL） and extranodal nasal-type NK/T-cell lymphoma （ENKTCL） were the common pathological types of primary Waldeyer＇s ring non-Hodgkin ]ymphoma accounting for 56 % （28/50） DLBCL and 34 % （17/50） ENKTCL, respectively. The age at onset of ENKTCL patients was younger than that of DLBCL patients. Two groups had different primary sites, including 50.0 % （14/28） of DLBCL with tonsillar disease and 88.2 % （15/17） of ENKTCL with nasopharynx disease. The short phase effect of DLBCL group was higher than that of ENKTCL group. The overall survival （OS） and progression-free survival （PFS） rates had significant differences between DLBCL and ENKTCL （χ2 = 4.45, P = 0.035; χ2 = 6.47, P = 0.011）. Conclusion DLBCL and ENKTCL are different in clinical characteristics. The short phase effect and prognosis of DLBCL are obviously better than those of the ENKTCL.