摘要
费城染色体样急性淋巴细胞白血病(Ph—likeALL)涉及与其高危特点和预后不良相关的多种基因组改变,如IKZF1、CRLF2、JAK1/2、EBF1-PDGFRB、ATF7IP、EPOR、SH283等。JAK/STAT途径和P13K/mTOR途径已被证实很可能是某些Ph.1ikeALL的相关靶点,文章重点综述以上基因组改变及治疗进展。
Ph-like acute lymphoblastic leukemia (Ph-like ALL) involves various genomic alterations associated with high risk factors and poor clinical outcome, such as IKZF1, CRLF2, JAK1/2, EBF1-PDGFRB, ATF7IP, EPOR, SH2B3. JAK/STAT pathway and PI3K/mTOR pathway are likely to be the targets of Ph-like ALL. Here,the above genomic alterations and treatment progress are reviewed.
出处
《白血病.淋巴瘤》
CAS
2015年第9期573-576,共4页
Journal of Leukemia & Lymphoma